Point-of-care estimation of haemoglobin concentration in neonates and infants
Method. In this prospective study we compared the analytical performance of the HemoCue with that of the Advia 120 haematology analyser with regard to accuracy, precision and linearity in the measurement of Hb in neonates and infants.
Results. Samples from 44 patients were analysed by both instruments and the results compared using difference plots. The mean Hb value for the HemoCue (11.8 g/dl; range 4.8 - 18.7) was comparable to that for the Advia (11.8 g/dl; range 5.2 - 19.2). The Bland-Altman difference plot revealed good agreement. Bias between the two methods was small and the imprecision was within acceptable limits. Hb measurement was linear in the range 4.8 - 20 g/dl.
Conclusion. In neonates and infants, the diagnostic accuracy of the HemoCue point of care device is comparable to that of the Advia 120 analyser. In neonatal and paediatric units, where the volume of blood available is limited and turnaround time critical, an appropriately quality-assured HemoCue can replace standard haematology analysers in the measurement of Hb.
Elise Schapkaitz, University of Witwatersrand and National Health Laboratory Service
Johnny Ndoni Mahlangu, University of Witwatersrand and National Health Laboratory Service
Matime Letsoalo, National Health Laboratory Service
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Date published: 2012-02-24
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