Case Reports

Neonatal HIV-associated nephropathy

R Bhimma, E Naicker, B W Mzimela

Abstract


Human immunodeficiency virus (HIV)-related nephropathy is a significant cause of morbidity and mortality in HIV-1 seropositive children in Africa that presents at any age. To date the youngest patient reported in the literature was from our centre, presenting at 4 months of age. We present here a neonate born to an HIV-1 infected mother on combined anti-retroviral therapy (cART), who had vertical transmission of the virus and presented with congenital nephrotic syndrome at three weeks of life. The child was confirmed to have HIV-1 infection at 6 weeks. Kidney biopsy showed features consistent with HIV-associated nephropathy. On commencement of cART and angiotensin converting enzyme antagonist treatment, there was a substantial decrease in proteinuria. To the best of our knowledge, this is the first report of HIV-associated nephropathy presenting as congenital nephrotic syndrome.


Authors' affiliations

R Bhimma, Department of Paediatrics and Child Health, School of Clinical Medicine, College of Health Science, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

E Naicker, Department of Paediatrics and Child Health, School of Clinical Medicine, College of Health Science, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

B W Mzimela, Department of Paediatrics and Child Health, Inkosi Albert Luthuli Central Hospital, Durban, KwaZulu-Natal, South Africa

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Cite this article

South African Journal of Child Health 2018;12(1):38-40. DOI:10.7196/SAJCH.2018.v12i1.1437

Article History

Date submitted: 2018-04-11
Date published: 2018-04-11

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